Bienvenue sur le site de l'équipe de Pharmacognosie,

Chimie des Substances Naturelles, Electrochimie 

UMR CNRS 8638 COMETE de l'Université Paris Descartes SPC



 Publication 2017

Antiscalant properties of Herniaria glabra aqueous solution,

Hermer O., Cheap-Charpentier H., Cachet X., Perrot H., Lédion J., Gélus D.,Pécoul N.                 Litaudon M., Roussi F.,

Desalination 409 (2017) 157-162.



Publications  2016


Catalytic oxidative coupling of primary amines under air: A flexible route to benzimidazole derivatives.

Nguyen K.M.H.; Largeron, M.

 Eur. J. Org. Chem., 2016, DOI:10.1002/ejoc.201501520


Detection of aristolochic acids I and II in "Chiniy-trèf", a traditional medicinal
preparation containing caterpillars feeding on Aristolochia trilobata L. in Martinique,
French West Indies.

Cachet X., Langrand J., Bottai C., Dufat H., Locatelli-Jouans C., Nossin E.,
Boucaud-Maitre D.,

 Toxicon, 2016, in press, accepted manuscript.




Publications  2015





"Symphonia globulifera, a widespread source of complex metabolites with potent biological activities" Y.

Fromentin, K. Cottet, M. Kritsanida, S. Michel, N. Gaboriaud-Kolar, M.-C. Lallemand, Planta Med., 2015, 81, 95-107.


"Isolation of Guttiferones from Renewable Parts of Symphonia globulifera by Centrifugal Partition Chromatography"

K. Cottet, Y. Fromentin, M. Kritsanida, R. Grougnet, G. Odonne, C. Duplais, S. Michel, M.-C. Lallemand

Planta Med., 2015, 81, 1-5.



Cymoside, a monoterpene indole alkaloid with a hexacyclic fused skeleton from Chimarrhis cymosa

Christelle Lémus,Marina Kritsanida, Alban Canet, Grégory Genta-Jouve, SylvieMichel, Brigitte Deguin,
Raphaël Grougnet

Tetrahedron Letters 2015, 56 (40), 5377-5380 


Viability of a [2+2+1] Hetero-Pauson-Khand Cycloaddition Strategy toward
Securinega Alkaloids: Synthesis of the BCD-Ring Core of Securinine and Related Alkaloids

Egor Chirkin, Sylvie Michel and François-Hugues Porée

J. Org. Chem. 2015, doi: 10.1021/acs.joc.5b011118


Chiroptical study and absolute configuration of securinine oxidation products

Egor Chirkin, William Atkatlian, Quyên Do, Thomas Gaslonde, Thi-Hanh Dufat, Sylvie Michel, Pascale Lemoine, Grégory Genta-Jouve & François-Hugues Porée.

Natural Product Research 2015,  10.1080/14786419.2015.1023727


A prenylated acridone alkaloid and ferulate xanthone from barks of Citrus medica (Rutaceae)

Marie Fomani, , Kouam,François-Hugues Porée , Marie-Christine Lallemand, Alain François Kamdem Waffo, Jean Duplex Wansi Z.
Naturforsch. B, 2015, 70, 71-75.

 Book Chapter:

E. Chirkin, W. Atkatlian, F.-H. Porée, The Securinega Alkaloids.

In The Alkaloids; Knölker, H-J., Ed.; 2015; pp 1–120.


COVER PICTURE: The isolation and synthesis of neodolastane diterpenoids

 Markovic, D.; Kolympadi, M.; Deguin, B.; Porée, F.-H.; Turks, M. Nat. Prod. Rep. 2015, 32, 230-255.





A Bioinspired catalytic aerobic oxidative C-H functionalization of primary aliphatic amines: synthesis of 1,2-disubstituted benzimidazoles.

Nguyen, K.M.H. Largeron, Martine.

Chem. Eur. J., 2015, 21, 12606-12610 (Hot Paper).



Polycyclic Polyprenylated Xanthones from Symphonia globulifera: Isolation and Biomimetic Electrosynthesis.

Cottet, K.; Neudörffer, A.; Kritsanida, M. ; Michel, S. ; Lallemand, M.-C. ; Largeron, M.

J. Nat. Prod., 2015, 78, 2136-2140.



Regiospecific synthesis of neuroprotective 1,4-benzoxazine derivatives through a tandem oxidation-Diels-Alder reaction.

Nguyen, K.M.H.  Schwendimann, L. Gressens, P. Largeron, M.

Org. Biomol. Chem. 2015, 13, 3749-3756.



A metalloenzyme-like catalytic system for the chemoselective oxidative cross-coupling of primary amines to imines under ambient conditions.

Martine Largeron, M. Fleury, M.-B.

Chem. Eur. J., 2015, 21, 3815-3820.