Accueil

 

Bienvenue sur le site de l'équipe de Pharmacognosie,

Produits Naturel, Analyse et Synthese

UMR 8038 CNRS-Université PARIS DESCARTES 

 

 

Publication 2019

 

 Severity of manchineel fruit (Hippomane mancinella) poisoning: a retrospective case series of 97 patients from French Poison Control Centers, Toxicon, Available online 28 February 2019,
In Press, Accepted Manuscript.

Denis Boucaud-Maitre, Xavier Cachet, Chouaha Bouzidi, Ludivine Riffault-Valois,Caroline Dupuy,               Robert Garnier, Jérôme Langrand,

 

 

Publication 2018

 

Clerodane furanoditerpenoids as the probable cause of toxic hepatitis induced by Tinospora crispa

Xavier Cachet,  Jerôme LangrandLudivine Riffault-ValoisChouaha BouzidiCyril ColasAnnabelle DugaySylvie Michel & Denis Boucaud-Maitre 

Scientific Reportsvolume 8, Article number: 13520 (2018)

 

  

 Publication 2017

Antiscalant properties of Herniaria glabra aqueous solution,

Hermer O., Cheap-Charpentier H., Cachet X., Perrot H., Lédion J., Gélus D.,Pécoul N.                 Litaudon M., Roussi F.,

Desalination 409 (2017) 157-162.

 

Publications  2016

 Catalytic oxidative coupling of primary amines under air: A flexible route to benzimidazole derivatives.

Nguyen K.M.H.; Largeron, M.

 Eur. J. Org. Chem., 2016, DOI:10.1002/ejoc.201501520

Detection of aristolochic acids I and II in "Chiniy-trèf", a traditional medicinal
preparation containing caterpillars feeding on Aristolochia trilobata L. in Martinique,
French West Indies.

Cachet X., Langrand J., Bottai C., Dufat H., Locatelli-Jouans C., Nossin E.,
Boucaud-Maitre D.,

 Toxicon, 2016, in press, accepted manuscript.

 

 

Publications  2015

"Symphonia globulifera, a widespread source of complex metabolites with potent biological activities" Y.

Fromentin, K. Cottet, M. Kritsanida, S. Michel, N. Gaboriaud-Kolar, M.-C. Lallemand, Planta Med., 2015, 81, 95-107.

 

"Isolation of Guttiferones from Renewable Parts of Symphonia globulifera by Centrifugal Partition Chromatography"

K. Cottet, Y. Fromentin, M. Kritsanida, R. Grougnet, G. Odonne, C. Duplais, S. Michel, M.-C. Lallemand

Planta Med., 2015, 81, 1-5.

  

Cymoside, a monoterpene indole alkaloid with a hexacyclic fused skeleton from Chimarrhis cymosa

Christelle Lémus,Marina Kritsanida, Alban Canet, Grégory Genta-Jouve, SylvieMichel, Brigitte Deguin,
Raphaël Grougnet

Tetrahedron Letters 2015, 56 (40), 5377-5380 

 


Viability of a [2+2+1] Hetero-Pauson-Khand Cycloaddition Strategy toward
Securinega Alkaloids: Synthesis of the BCD-Ring Core of Securinine and Related Alkaloids

Egor Chirkin, Sylvie Michel and François-Hugues Porée

J. Org. Chem. 2015, doi: 10.1021/acs.joc.5b011118

 

Chiroptical study and absolute configuration of securinine oxidation products

Egor Chirkin, William Atkatlian, Quyên Do, Thomas Gaslonde, Thi-Hanh Dufat, Sylvie Michel, Pascale Lemoine, Grégory Genta-Jouve & François-Hugues Porée.

Natural Product Research 2015,  10.1080/14786419.2015.1023727

 

A prenylated acridone alkaloid and ferulate xanthone from barks of Citrus medica (Rutaceae)

Marie Fomani, , Kouam,François-Hugues Porée , Marie-Christine Lallemand, Alain François Kamdem Waffo, Jean Duplex Wansi Z.
Naturforsch. B, 2015, 70, 71-75.

 Book Chapter:

E. Chirkin, W. Atkatlian, F.-H. Porée, The Securinega Alkaloids.

In The Alkaloids; Knölker, H-J., Ed.; 2015; pp 1–120.

 

COVER PICTURE: The isolation and synthesis of neodolastane diterpenoids

 Markovic, D.; Kolympadi, M.; Deguin, B.; Porée, F.-H.; Turks, M. Nat. Prod. Rep. 2015, 32, 230-255.

 

 

 

 

A Bioinspired catalytic aerobic oxidative C-H functionalization of primary aliphatic amines: synthesis of 1,2-disubstituted benzimidazoles.

Nguyen, K.M.H. Largeron, Martine.

Chem. Eur. J., 2015, 21, 12606-12610 (Hot Paper).

 

Polycyclic Polyprenylated Xanthones from Symphonia globulifera: Isolation and Biomimetic Electrosynthesis.

Cottet, K.; Neudörffer, A.; Kritsanida, M. ; Michel, S. ; Lallemand, M.-C. ; Largeron, M.

J. Nat. Prod., 2015, 78, 2136-2140.

 

Regiospecific synthesis of neuroprotective 1,4-benzoxazine derivatives through a tandem oxidation-Diels-Alder reaction.

Nguyen, K.M.H.  Schwendimann, L. Gressens, P. Largeron, M.

Org. Biomol. Chem. 2015, 13, 3749-3756.

 

A metalloenzyme-like catalytic system for the chemoselective oxidative cross-coupling of primary amines to imines under ambient conditions.

Martine Largeron, M. Fleury, M.-B.

Chem. Eur. J., 2015, 21, 3815-3820.

 

 

 

exandas

Horizon 2020

Call: H2020-MSCA-RISE-2015

Topic: MSCA-RISE-2015

Action: MSCA-RISE

Début du projet : mars 2016

Durée : 4 ans

 

 

Le Laboratoire de Pharmacognosie (Pr S. Michel Responsable scientifique, Dr Marina Kritsanida, Dr Sabrina Boutefnouchet, Dr Raphaël Grougnet) participe au projet européen EXANDAS : “Exploitation of aromatic plants’ by-products for the development of novel cosmeceuticals and food supplements” (MSCA-RISE-2015, Grant Agreement No 691247) qui réunit 6 Institutions académiques et 6 PME de 7 pays d’Europe et d’Afrique du Nord (Grèce, France, Allemagne, Bulgarie, Maroc, Algérie, Tunisie).

Link: https://www.exandas-project.eu/